Morinda citrifolia is a fruitbearing tree in the coffee family, rubiaceae. Morinda citrifolia noni has been used widely as a complementary and alternative therapy in many countries owing to its potent antioxidant activity and proven health benefits. Our preliminary data indicated that 10% tahitian noni liquid dietary supplement or tahitian noni juice tnj, made from morinda citrifolia fruit by morinda inc, in drinking water for one week was able to prevent dmbadna adduct formation. Sathish kumar studies of comparative antihiv activity and cytotoxicity of morinda citrifolia l. It is distributed from asia, pacific to caribbean region. One of the many uses for morinda citrifolia is for its medicinal properties. Research article morinda citrifolia noni alters oxidative. During one 4month period, i lived in a thatched house with a ura noni tree adjacent to the entry doorway. Abstract morinda citrifolia commonly known as noni is a perennial plant. In fact, many cultures in burma and australia this fruit is a vital part of their diet. Morinda citrifolia noni juice was prepared in the laboratory of pharmacognosy of university of uberaba, in uberaba, minas gerais, brazil. Though mostly referred to as the noni, morinda citrifolia has an abundance of common names in a lot of different languages. Morinda citrifolia an overview sciencedirect topics. Damnacanthal, an anthraquinone compound, is isolated from the roots of morinda citrifolia l.
Literatures prove that noni is pharmacologically active and is used in different forms of cancer, viz. Cancer preventive effect of morinda citrifolia noni doc. Due to its versatility of adaptation and use of the structures of the plant for different therapeutic purposes, noni attracted the attention of researchers from the pharmaceutical and food industry. Morinda citrifolia fruit like for cancer, infection, arthritis. Although noni has been consumed for a long time in asian and polynesian countries, the molecular mechanisms by which it exerts several benefits are starting to emerge. Noni morinda citrifolia is a medicinal plant from pacific regionsevidence on the effects in cancer patients is lacking. Experimental study international journal of medicinal plants and natural products ijmpnp page 9 it is valid to consider that the juice produced from morinda citrifolia linn is made with the ripe fruit. Two novel glycosides from the fruits of morinda citrifolia. Experimental study international journal of medicinal plants and natural products ijmpnp page 9 it is valid to consider that the juice produced from morinda citrifolia linn is made with the ripe fruit and its. Induction of mitochondrialmediated apoptosis by morinda citrifolia noni in human cervical cancer cells. The noni fruit journal of medicinal plants studies. Early research suggests that taking 68 grams of noni daily might improve physical function, fatigue, and pain in people with advanced cancer. Morinda citrifolia is a yellowish color and the fruits have a unique and distinct disagreeable odor when ripe.
Genetics there is a relatively high degree of genetic e. Noni is the common name for morinda citrifolia l and is also called indian mulberry, ba ji tian, nono or nonu, cheese fruit, and nhau in various cultures throughout the world. Type i collagenstimulating effect was exhibited by the 1,4dihydroxy2methoxy7methylanthraquinone figure 67. Phytochemical constituents and activities of morinda citrifolia l. The fruits were mechanically depulped using a fruit depulper. The first consisted of testing freezedried noni fruit, which reduced pain perception, but did not reverse advanced cancer. Cancer preventive effect of morinda citrifolia noni. Traditionally, it finds used as a therapeutic remedy to various diseases as an antibacterial, antitumor, anthelminthic, analgesic, antiinflammatory, immunostimulant. Morinda citrifolia, also known as noni, has been used for hundreds of years throughout polynesia for a variety of conditions.
Uses, side effects, interactions, dosage, and warning. These plant parts have shown antioxidant, antimicrobial, anticancer and antiinflammatory properties. Nci dictionary of cancer terms national cancer institute. Pdf anticancer activity of morinda citrifolia noni fruit. Xeronine found in morinda citrifolia noni fruit nirav r soni department of quality assurance qa, gtu, ahmedabad aone pharmacy college, ahmedabad, india. Noni, with the botanical name morinda citrifolia is a medicinal plant which is used as a natural nutritional food supplement world wide for centuries. Morinda citrifolia rubiaceae, known as noni locally, is a plant grown in the hawaiian and tahitian islands. Chemical constituents of the fruits of morinda citrifolia. Morinda citrifolia noni alters oxidative stress markers and antioxidant activity in cervical cancer cell lines. Pdf morinda citrifolia edible leaf extract enhanced immune. The hypothesis that morinda citrifolia possesses a cancer preventive effect at. Morinda citrifolia noni reduces cancer risk in current smokers by decreasing aromatic dna adducts. Effect of morinda citrifolia linn on lung cancer promotion. Umezawa cancer letters 73 1993 161166 in this study, a team of japanese researchers studied the effect of over 500 extracts from tropical plants on the krasnrk cell, a precursor to certain types of cancer.
It has been reported to have a broad range of health benefits for cancer, infection, arthritis, diabetes, asthma, hypertension, and pain6. Morinda citrifolia possesses a cancer preventive effect at the initiation stage of carcinogenesis was studied. Derived from the two latin words mor us, mulberry, and indicus, indian, in reference to the similarity o f the fruit of noni to that o f t. Abstract morinda citrifolia commonly known as noni is a perennial plant originating. Wo2002083159a1 palliative effects of morinda citrifolia. In the search for functional foods as complementary therapies against lung cancer, the. Antiinflammatory and potential cancer chemopreventive constituents of the fruits of morinda citrifolia noni. Morinda citrifolia leaf has antiinflammatory and immune enhancing effects against lung cancer. Anticancer effects of extracts from the fruit of morinda citrifolia noni in breast cancer cell lines. Morinda citrifolia noni juice augments mammary gland.
It has been reported to have broad therapeutic effects including anticancer activity. Acute liver failure in a patient consuming herbalife products and noni juice. Morinda citrifolia l noni has been used in folk remedies by polynesians for over 2000 years, and is reported to have a broad range of therapeutic effects, including antibacterial, antiviral, antifungal, antitumor, antihelmin, analgesic, hypotensive, antiinflammatory, and immune enhancing effects. Among some 100 names for the fruit across different regions are the more common english names of great morinda, indian. Morinda citrifolia should not be confused with morinda officinalis, also known as ba ji tian, which is commonly used in chinese medicine. Health benefits of morinda citrifolia noni pharmacognosy journal.
Traditionally, people of these regions have been using noni fruits for healing and prevention of various diseases such as cancer, arthritis, and hypertension. In the current study, we investigated the effects of noni fruit juice nfj in the treatment of c57bl6 mice, which were continuously exposed to dextran sulfate sodium dss for 9 consecutive days. It is a glabrous shrubsmall tree believed to be native to the southeast asia and tropical. Pdf induction of mitochondrialmediated apoptosis by. Mar 30, 2012 morinda citrifolia is used for those with, immune disorders, cancer, colds, arthritis depression, hypertension and pain. Immunomodulation contributes to the anticancer activity of morinda citrifolia noni fruit juice. Damnacanthal, a noni component, exhibits antitumorigenic. Properties and applications of morinda citrifolia noni. These plant parts have shown antioxidant, antimicrobial, anti cancer and anti.
The scientific name of noni is morinda citrifolia l. A medline search was conducted using the key search words morinda citrifolia and morinda citrifolia and cancer 1964 to october, 2011 along with crossreferencing. Breast cancer prevention with morinda citrifolia noni at the initiation stage mianying wang, lin peng, gary anderson, diane nowicki department of pathology, university of illinois college of medicine, rockford, il 61107 corresponding author. Morinda citrifolia commonly known as noni is a perennial plant originating in southeast asia, consumed over 2000 years. Morinda citrifolia has been reported to help in a plethora of issues. It is also used to prevent the formation and proliferation of tumours including malignant neoplasm. Morinda citrifolia noni fruit juice nfj, 2 ml per kg bw per day, was consumed by twenty patients with dt2 after they underwent a standard treatment regimen. Mianying wang, md, research associate professor, department of. Morinda citrifolia was especially esteemed by the ancient aryan physicians because it protected the skin from becoming dry and cracked from the sun. Noni fruits morinda citrifolia, also known as indian mulberry, are indigenous to sea, australasia, hawaii, and tahiti. Its native range extends across southeast asia and australasia, and the species is now cultivated throughout the tropics and widely naturalized.
Morinda citrifolia noni fruit juice reduces inflammatory. View the article pdf and any associated supplements and figures for a period of 48 hours. The fruit juice of morinda citrifolia or noni contains a. Morinda citrifolia noni dna repair genes cervical cancer siha cells research article influence of morinda citrifolia noni on expression of dna repair genes in cervical cancer cells rakesh kumar gupta, deepti bajpai, neeta singh in malignant cells, the suppression of dna repair would. It has been shown to be immune system modulating, anti cancer, antidiabetic, a strong antimicrobial and to enhance cognitive abilities, etc. Purification of a nbuohsoluble partition of the meoh extract of morinda citrifolia noni fruits led to the isolation of two new iridoid glucosides, 6. Cervical cancer is the second most common cause of cancer in women and has a high mortality rate. The effects of the extract on metastasised lung and liver cancer. However, the administration of cisplatin is associated with side effects and. The species name citrifolia indicates that the plants foliage is similar to that of a citrus species, such as oranges. In the last ten years has noni juice become better known to the western world with thousands of users reporting positive results. The us national cancer institute is funding preliminary studies of noni for breast cancer prevention and treatment. The effect of the daily consumption of morinda citrifolia noni fruit juice on the physiological status of patients with diabetes type 2 dt2 was tested over a period of two months. Wo2002083159a1 palliative effects of morinda citrifolia oil.
Two novel glycosides from the fruits of morinda citrifolia noni inhibit ap1 transactivation and cell transformation in the mouse epidermal jb6 cell line. Periyasamy selvam, narayanan murugesh andmyriam witvrouw. Morinda citrifolia noni reduces cancer risk in current. Distinguished by its cocoonlike shape and pungent odor, morinda citrifolia is reputed to have remarkable health and medicinal benefits. However, data concerning its role in the treatment of intestinal inflammation still require clarification. Sultan ahmad and others published cancer preventive effect of morinda citrifolia noni fruit juice against the. Morinda citrifolia noni reduces cancer risk in current smokers by decreasing aromatic dna adducts mian ying wang, lin peng, may nawal lutfiyya, eric henley, vicki weidenbacherhoper, gary anderson administration ahc. Morinda citrifolia noni is reported to have many beneficial properties, including on immune, inflammatory, quality of life, and cancer endpoints, but little is. The stem, bark, root, leaf, and fruits of the plant have been used traditionally by islanders as medicines to treat a broad range of diseases, including diabetes, hypertension, and cancer 1, 2. Jan 25, 2006 the hypothesis that morinda citrifolia possesses a cancer preventive effect at the initiation stage of carcinogenesis was studied.
Garridogallego f, munozgomez r, munozcodoceo c, et al. Although noni has been consumed for a long time in asian and polynesian countries, the molecular mechanisms by which it exerts several benefits are. Anticancer activity of morinda citrifolia noni fruit. Early research suggests that taking 68 grams of noni daily might improve physical function. It was observed that morinda citrifolia fruit extract initiated the biosynthesis of type i collagen and glycosaminoglycans in cultures of normal human fibroblasts. It is a glabrous shrubsmall tree believed to be native to the southeast asia and tropical northern australia. Nonis effect to cure cancer is at the cellular level. An extract from the fruit is being studied as a treatment for cancer, and extracts from the fruit, leaves, or roots have been used in some cultures to treat other diseases. Wo2002083159a1 pctus2002012170 us0212170w wo02083159a1 wo 2002083159 a1 wo2002083159 a1 wo 2002083159a1 us 0212170 w us0212170 w us 0212170w wo 02083159 a1 wo02083159 a1 wo 02083159a1 authority wo wipo pct prior art keywords cox morinda citrifolia method juice cancer prior art date 20010417 application number. Novel treatment of cancer and its potential in obesity. Morinda citrifolia, commonly known as noni, is the fruit of a tree native to southeast asia, where it has been consumed for 2,000 years.
A medline search was conducted using the key search words morinda citrifolia and morinda citrifolia and cancer 1964 to october, 2011 along with cross. Morinda citrifolia listen mohrinduh sihtrihfohleeuh a tropical shrub. Examples of remedies employing m citrifolia are listed in table 2. Traditionally, it finds used as a therapeutic remedy to various diseases as an antibacterial, antitumor, anthelminthic, analgesic, antiinflammatory. Cisplatin, an antitumor agent, is generally used for its treatment. It has been shown to be immune system modulating, anticancer, antidiabetic, a strong antimicrobial and to enhance cognitive abilities, etc. Pdf anticancer activity of morinda citrifolia noni. Noni morinda citrifolia, also known as ba ji tian, cheese fruit and indian mulberry, is a polynesian plant that has traditionally been used in medicinal remedies. Polynesian healer used this plant for thousands of years to prepare effective remedies to various health challenges. Cancer preventive effect of morinda citrifolia noni wang. Antiinflammatory and potential cancer chemopreventive. Morinda citrifolia leaf extract suppressed metastasised cancer. Noni fruit juice has been the main focus of attention in recent years.
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